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KMID : 0377220010260010007
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Medical Journal of Chosun Univercity
2001 Volume.26 No. 1 p.7 ~ p.15
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Immunohistochemical study on the postnatal development of Ca^2+ -binding protein calbindin-D28K containing neurons in the amygdala of the rat
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Chung Yoon-Young
Kim Jong-Joong
Moon Jeong-Seok
Park Young-Lan
Jeong Sang-Bong
Kim Hyun-Kon
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Abstract
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Background and Objectives : The calcium-binding protein, calbindin-D28K(CB) is widely distribution of CB in rat amygdala during postnatal maturation, in order to provide an insight into the developmental role it may play in the amygdaloid neurons.
Materials and Methods : The present study is based on 28 postnatal cases ranging from the day of birth, postnatal day 0 (P0) to 30 days (P5, P10, P15, P20, P30), and these cases were compared with adult rat amygdala. Cryostat sections processed free-floating with monoclonal antibody by immunohistochemistry.
Results : CB-immunoreactive neurons were already found at birth in all amygdaloid nuclei except the intercalated nucleus. The intensity and number of immunoreactivity of CB-containing neurons increased during the first 10 days of postnatal life but dramatically decreased at P15. Mature patterns of CB-immunoreactive neurons were achieved at P20. In the adult amygdala, CB-immunoreactive neurons were distributed in almost all amygdaloid nuclei except the intercalated nucleus.
Conclusion : The present results show early appearance of CB immunoreactivity in the amygdala. It may be related to the early appearance of CB immunoreactivity in many other brain regions, and suggests that CB may play a functional role during the development of the nervous system including amygdala.
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KEYWORD
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Rat, Amygdata, Calbindin-D28K, Postnatal development, Immunohistochemistry
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